Dual circuits originating from the ventral hippocampus independently facilitate affective empathy

Dual circuits originating from the ventral hippocampus independently facilitate affective empathy

Blog Article

Summary: Affective empathy enables social mammals to Box Bag learn and transfer emotion to conspecifics, but an understanding of the neural circuitry and genetics underlying affective empathy is still very limited.Here, using the naive observational fear between cagemates as a paradigm similar to human affective empathy and chemo/optogenetic neuroactivity manipulation in mouse brain, we investigate the roles of multiple brain regions in mouse affective empathy.Remarkably, two neural circuits originating from the ventral hippocampus, previously unknown to function Spring Riding Toys in empathy, are revealed to regulate naive observational fear.One is from ventral hippocampal pyramidal neurons to lateral septum GABAergic neurons, and the other is from ventral hippocampus pyramidal neurons to nucleus accumbens dopamine-receptor-expressing neurons.

Furthermore, we identify the naive observational-fear-encoding neurons in the ventral hippocampus.Our findings highlight the potentially diverse regulatory pathways of empathy in social animals, shedding light on the mechanisms underlying empathy circuity and its disorders.